There are two types of cholesterol: LDL and HDL. Doctors call HDL the “Good Cholesterol” because your body needs it. Conversely, LDL is considered to be the “Bad Cholesterol” because high levels of LDL cholesterol are associated with conditions such as heart attack and stroke. Think of your liver as a cholesterol factory. It creates cholesterol at night while you are sleeping. Crestor works directly in the liver, inhibiting the enzyme that manufactures the bad cholesterol (LDL) while leaving the production of HDL alone. By inhibiting or blocking the action of this liver enzyme, your body's ability to produce LDL (bad) cholesterol is dramatically reduced. However, while Crestor does lower LDL (bad) cholesterol, it has a limited effect on HDL (good) cholesterol, and no effect on triglycerides (fats), an equally dangerous heart disease risk indicator.
AstraZeneca Pharmaceuticals, LP (the Crestor drug manufacturer) recommends that liver function tests be performed before someone begins Crestor therapy and at 12 weeks following both the initiation of therapy and any elevation of dose, and periodically (e.g., semiannually) thereafter. In most cases, people with vastly elevated liver enzymes should stop taking Crestor immediately.
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