Actos contains pioglitazone, which may be harmful for patients with bladder cancer. Therefore, on August 4, 2011 the FDA informed the public thorough a Safety Communication (https://www.fda.gov/Drugs/DrugSafety/ucm266555.htm), that it approved an update to the drugs warning label. The purpose of the update was to inform the public that using Actos for more than one year may increase the risk of bladder cancer.
The following are the updated changes to the label:
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